Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition
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چکیده
منابع مشابه
Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition.
The aspartate-specific caspases are critical protease effectors of programmed cell death and consequently represent important targets for apoptotic intervention. Baculovirus P35 is a potent substrate inhibitor of metazoan caspases, a property that accounts for its unique effectiveness in preventing apoptosis in phylogenetically diverse organisms. Here we report the 2.2 A resolution crystal stru...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1999
ISSN: 1460-2075
DOI: 10.1093/emboj/18.8.2031